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Poorer Neurodevelopmental Outcomes Associated with Cystoid Macular Edema Identified in Preterm Infants in the Intensive Care Nursery



شناسه مقاله
10.1016/j.ophtha.2014.09.022
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انگلیسی

Title: Poorer Neurodevelopmental Outcomes Associated with Cystoid Macular Edema Identified in Preterm Infants in the Intensive Care Nursery

Authors: Adam L. Rothman and Du Tran-Viet and Kathryn E. Gustafson and Ricki F. Goldstein and Maureen G. Maguire and Vincent Tai and Neeru Sarin and Amy Y. Tong and Jiayan Huang and Laura Kupper and C. Michael Cotten and Sharon F. Freedman and Cynthia A. Toth

Journal: Ophthalmology

Year: 2015

Abstract:

Purpose To evaluate the association between cystoid macular edema (CME) observed in very preterm infants and developmental outcomes at 18 to 24 months corrected age. Design Cohort study. Participants Infants born at or less than 1500 g or at or less than 30 weeks postmenstrual age who underwent screening for retinopathy of prematurity (ROP) in an intensive care nursery. Methods Bedside handheld spectral-domain optical coherence tomography (SD OCT; Envisu, Bioptigen, Inc, Research Triangle Park, NC) imaging was obtained from preterm infants who were being screened for {ROP} and graded for presence of CME, central foveal thickness (CFT), inner nuclear layer thickness, and foveal-to-parafoveal thickness ratio. At 18 to 24 months corrected age, the children were assessed with the Bayley Scales of Infant and Toddler Development, Third Edition. Main Outcome Measures Scores on the Bayley cognitive, language, and motor subscales. Results Among 77 children with {SD} {OCT} imaging, 53 were evaluated with the Bayley Scales. Compared with children who did not have {CME} as infants (n = ۲۲), the mean score for children who had {CME} (n = ۳۱) was 7.3 points (95% confidence interval [CI], −۱۵٫۵ to 0.9; P = ۰٫۰۸) lower on the cognitive subscale, 14.1 points (95% CI, −۲۲٫۷ to −۵٫۵; P = ۰٫۰۰۲) lower for the language subscale, and 11.5 points (95% CI, −۲۱٫۶ to −۱٫۳; P = ۰٫۰۳) lower for the motor subscale. Differences were maintained after adjusting for gestational age and birth weight. Severity of CME, as assessed by foveal-to-parafoveal thickness ratio, within the {CME} group correlated with poorer cognitive (R2 = ۰٫۱۶, P = ۰٫۰۳) and motor (R2 = ۰٫۱۵, P = ۰٫۰۳) development. Conclusions Cystoid macular edema observed on {SD} {OCT} in very preterm infants screened for {ROP} is associated with poorer language and motor skills at 18 to 24 months corrected age. Evaluation of the retina with SD-OCT may serve as an indicator of neurodevelopmental health for very preterm infants in the intensive care nursery.

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نویسندگان: Adam L. Rothman and Du Tran-Viet and Kathryn E. Gustafson and Ricki F. Goldstein and Maureen G. Maguire and Vincent Tai and Neeru Sarin and Amy Y. Tong and Jiayan Huang and Laura Kupper and C. Michael Cotten and Sharon F. Freedman and Cynthia A. Toth

ژورنال: Ophthalmology

سال: ۲۰۱۵

چکیده:
بررسی شبکیه چشم با SD-اکتبر ممکن است به عنوان شاخص سلامت عصبی تکاملی برای نوزادان بسیار نارس در مهد کودک مراقبت های ویژه در خدمت
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