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Perinatal exposure to dioxins and dioxin-like compounds and infant growth and body mass index at seven years: A pooled analysis of three European birth cohorts



شناسه مقاله
10.1016/j.envint.2016.04.040
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انگلیسی

Title: Perinatal exposure to dioxins and dioxin-like compounds and infant growth and body mass index at seven years: A pooled analysis of three European birth cohorts

Authors: Nina Iszatt and Hein Stigum and Eva Govarts and Lubica Palkovicova Murinova and Greet Schoeters and Tomas Trnovec and Juliette Legler and Cathrine Thomsen and Gudrun Koppen and Merete Eggesbø

Journal: Environment International

Year: 2016

Abstract:

AbstractBackground Dioxins and dioxin-like compounds are endocrine disrupting chemicals (EDCs). Experimental studies suggest perinatal exposure to {EDCs} results in later obesity. However, the few epidemiological investigations on dioxins are inconclusive. We investigated perinatal exposure to dioxins and dioxin-like compounds, infant growth and body mass index (BMI) in childhood. Methods We pooled data from 3 European birth cohorts (Belgian, Norwegian, Slovak) with exposure assessment in cord blood or breast milk. Two cohorts had dioxin-like toxicity assessed using dioxin-responsive chemical-activated luciferase expression (DR-CALUX) bioassay and one cohort had measured concentrations of dioxins, furans and dioxin-like polychlorinated biphenols with {CALUX} relative potency values applied. Growth was cohort- and sex-specific change in weight-for-age z-score between birth and 24 months (N = 367). {BMI} was calculated at around 7 years (median 7.17, interquartile range [IQR] 7.00–۷٫۳۷ years, N = 251), and overweight defined according to international standards for children equivalent to adult {BMI} > 25 kg/m2 (Cole and Lobstein, 2012). We fitted multivariate models using generalized estimating equations, and tested effect modification by sex, breastfeeding and cohort. Results per 10 pg {CALUX} TEQ/g lipid increase in exposure. Results Dioxin exposure was highest in the Belgian and lowest in the Norwegian cohort; median (IQR) of the pooled sample 13 (12.0) pg {CALUX} TEQ/g lipid. Perinatal exposure to dioxins and dioxin-like compounds appeared associated with increased growth between 0 and 24 months (adjusted estimate for change in z-score: β = ۰٫۰۷, ۹۵% CI: − ۰٫۰۱, ۰٫۱۴). At 7 years, dioxins exposure was associated with a statistically significant increase in {BMI} in girls (adjusted estimate for {BMI} units β = ۰٫۴۹, ۹۵% CI: 0.07, 0.91) but not in boys (β = − ۰٫۰۳, ۹۵% CI: − ۰٫۵۵, ۰٫۴۹) (p-interaction = 0.044). Furthermore, girls had a 54% (− ۶%, ۱۵۱%) increased risk of overweight at 7 years (p-interaction = 0.023). Conclusion Perinatal exposure to dioxin and dioxin-like compounds was associated with increased early infant growth, and increased {BMI} in school age girls. Studies in larger sample sizes are required to confirm these sex-specific effects.

Keywords: Dioxins, Dioxin-like PCBs, Birth cohorts, Infant growth, BMI, Obesity

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عنوان: قرار گرفتن در معرض پری ناتال به دیوکسین و ترکیبات دیوکسین مانند و رشد نوزاد و شاخص توده بدن در هفت سال: تجزیه و تحلیل حاصل از سه گروه از تولد اروپا

نویسندگان: Nina Iszatt and Hein Stigum and Eva Govarts and Lubica Palkovicova Murinova and Greet Schoeters and Tomas Trnovec and Juliette Legler and Cathrine Thomsen and Gudrun Koppen and Merete Eggesbø

ژورنال: Environment International

سال: ۲۰۱۶

چکیده:
۴۹) (P-تعامل = ۰۰۴۴) علاوه بر این، دختران به ۵۴٪ (- ۶٪، ۱۵۱٪) افزایش خطر ابتلا به اضافه وزن در ۷ سال (P-تعامل = ۰۰۲۳) نتیجه گیری قرار گرفتن در معرض پری ناتال به ترکیبات دیوکسین و دیوکسین مانند همراه بود با افزایش رشد نوزاد اولیه، و افزایش {BMI} در دختران سن مدرسه مطالعات انجام شده در حجم نمونه مورد نیاز برای تایید آن جنس خاص
کلمات کلیدی:   دیوکسین، PCB ها، دیوکسین مانند، گروه های تولد، رشد نوزادان، BMI، چاقی

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