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Effects of Placental Inflammation on Neonatal Outcome in Preterm Infants



شناسه مقاله
10.1016/j.pedneo.2013.05.007
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انگلیسی

Title: Effects of Placental Inflammation on Neonatal Outcome in Preterm Infants

Authors: Zhiwei Liu and Zheng Tang and Juan Li and Yi Yang

Journal: Pediatrics & Neonatology

Year: 2014

Abstract:

Background Intrauterine infection is the most commonly identified cause of preterm birth. In this study, our aim was to determine the association between placental inflammation and neonatal outcome in a prospective observational cohort of preterm infants of less than 34 weeks gestational age. We especially focused on the distinct effects of maternal inflammatory response (MIR) with and without fetal inflammatory response (FIR). Methods Clinical characteristics and placental histological results were prospectively collected from 216 singleton infants born at a gestational age of less than 34 weeks. Results Of the 216 newborns, 104 (48.1%) infants had histological placental inflammation. Based on their pathological findings, the premature infants were divided into three groups: (1) the {MIR} negative−FIR negative (MIR−FIR−) group; (2) the {MIR} positive−FIR positive (MIR+FIR+) group; and (3) the {MIR} positive–FIR negative (MIR+FIR−) group. The incidence of neonatal respiratory distress syndrome (RDS) in the MIR+FIR− group (5.7%) and in the MIR+FIR+ group (2.0%) was significantly lower than in the MIR−FIR− group (19.6%) (p < ۰٫۰۵). Logistic regression analysis showed that MIR+FIR+ group had a decreased incidence of neonatal {RDS} (OR = ۰٫۰۷۶; ۹۵% {CI} 0.009–۰٫۶۲۴; p = ۰٫۰۱۶). The incidence of intraventricular hemorrhage (IVH) Grade 2 or greater was significantly higher in the MIR+FIR+ group (42.3%) than in the MIR+FIR− group (13.0%) (p < ۰٫۰۵) or in the MIR−FIR− group (15.2%) (p < ۰٫۰۵). Logistic regression analysis also showed that MIR+FIR+ was associated with an increased incidence of {IVH} Grade 2 or greater (OR = ۴٫۰۸; ۹۵% {CI} 1.259–۱۳٫۲۴; p = ۰٫۰۱۹). Conclusion A positive {MIR} in association with a positive {FIR} decreases the risk of RDS, but increases the risk of {IVH} Grade 2 or greater in preterm infants with a gestational age of less than 34 weeks. However, a positive {MIR} alone has little effect on neonatal outcome.

Keywords: intraventricular hemorrhage, neonatal outcome, placental inflammation, preterm infants, respiratory distress syndrome

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عنوان: اثر جفت التهاب بر پیامد نوزادان در نوزادان نارس

نویسندگان: Zhiwei Liu and Zheng Tang and Juan Li and Yi Yang

ژورنال: Pediatrics & Neonatology

سال: ۲۰۱۴

چکیده:
با این حال، مثبت {MIR} تنهایی اثر کمی بر روی پیامد نوزادان
کلمات کلیدی:   خونریزی داخل بطنی، پیامد نوزادان، التهاب جفت، نوزادان نارس، سندرم زجر تنفسی

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