» مقالات انگلیسی » Anti-Group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection

Anti-Group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection



شناسه مقاله
10.1016/j.vaccine.2014.12.025
دریافت مقاله

انگلیسی

Title: Anti-Group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection

Authors: Kirsty Le Doare and Lauren Allen and Beate Kampmann and Paul Trafford Heath and Stephen Taylor and Anneke C. Hesseling and Andrew Gorringe and Christine Elizabeth Jones

Journal: Vaccine

Year: 2015

Abstract:

AbstractBackground HIV-exposed uninfected infants have increased infection risk and mortality compared to HIV-unexposed infants. HIV-exposed infants may be at increased risk of invasive {GBS} disease due to reduced maternal antibody against GBS. Methods We quantified antibodies that bind to the surface of whole Group B Streptococcus (GBS) of serotypes Ia, Ib, II, {III} and V using novel flow cytometry assays in South African HIV-infected and non-infected mothers and their uninfected infants. Antibody-mediated complement C3b/iC3b deposition onto {GBS} of these serotypes was also quantified by a novel flow cytometry assay. Results Geometric mean concentration (GMC) of both surface-binding anti-GBS antibody and antibody-mediated complement deposition onto {GBS} were reduced in HIV-infected women (n = 46) compared to HIV-uninfected women (n = 58) for {ST1a} (surface-binding: 19.3 vs 29.3; p = 0.003; complement deposition: 2.9 vs 5.3 SU/mL; p = 0.003), {STIb} (24.9 vs 47.6; p = 0.003; 2.6 vs 4.9 SU/mL; p = 0.003), {STII} (19.8 vs 50.0; p = 0.001; 3.1 vs 6.2 SU/mL; p = 0.001), {STIII} (27.8 vs 60.1; p = 0.001; 2.8 vs 5.3 SU/mL; p = 0.001) and {STV} (121.9 vs 185.6 SU/mL; p < 0.001) and in their infants for {STIa} (complement deposition 9.4 vs 27.0 SU/mL; p = 0.02), {STIb} (13.4 vs 24.5 SU/mL; p = 0.02), {STII} (14.6 vs 42.7 SU/mL; p = 0.03), {STIII} (26.6 vs 62.7 SU/mL; p = 0.03) and {STV} (90.4 vs 165.8 SU/mL; p = 0.04). Median transplacental transfer of antibody from HIV-infected women to their infants was reduced compared to HIV-uninfected women for {GBS} serotypes {II} (0.42 [IQR 0.22–۰٫۵۹] vs 1.0 SU/mL [0.42–۱٫۶۶]; p < 0.001), {III} (0.54 [0.31–۱٫۰۳] vs 0.95 SU/mL [0.42–۳٫۰۵], p = 0.05) and V (0.51 [0.28–۰٫۷۹] vs 0.75 SU/mL [0.26–۲٫۹], p = 0.04). The differences between infants remained significant at 16 weeks of age. Conclusions Maternal {HIV} infection was associated with lower anti-GBS surface binding antibody concentration and antibody-mediated C3b/iC3b deposition onto {GBS} bacteria of serotypes Ia, Ib, II, {III} and V. This may render these infants more susceptible to early and late onset {GBS} disease.

Keywords: Antibody, Group B Streptococcus, HIV-exposed-uninfected infants, HIV, Immunity

ترجمه فارسی
این متن به صورت خودکار و توسط موتور مترجم ترجمه شده است. برای سفارش ترجمه دقیق به قسمت 'سفارش ترجمه' مراجعه کنید

عنوان: آنتی بادی ضد استرپتوکوک گروه B در نوزادان متولد شده از مادران مبتلا به ویروس نقص ایمنی انسانی (HIV) به

نویسندگان: Kirsty Le Doare and Lauren Allen and Beate Kampmann and Paul Trafford Heath and Stephen Taylor and Anneke C. Hesseling and Andrew Gorringe and Christine Elizabeth Jones

ژورنال: Vaccine

سال: ۲۰۱۵

چکیده:
نتیجه گیری مادر {HIV} عفونت با سطح ضد GBS پایین تر در ارتباط اتصال غلظت آنتی بادی و آنتی بادی واسطه رسوب C3B / iC3b بر روی {GBS} باکتری سروتیپ IA، IB، II، {III} و V این ممکن است این نوزادان رندر بیشتر در معرض به شروع زودهنگام و مرحوم {GBS} بیماری
کلمات کلیدی:   آنتی بادی، استرپتوکوک گروه B، نوزادان مبتلا به ایدز در معرض-عفونی نیست.استفاده، HIV، ایمنی

سفارش ترجمه

سفارش ترجمه

توانایی ترجمه

توانایی ترجمه

  • فیلد های زیر را به عنوان نمونه کار ترجمه کنید. دقت کنید که کیفیت ترجمه در انتخاب شما به عنوان مترجم این مقاله موثر است.


دریافت مقاله