» مقالات انگلیسی » Adaptive regulation of amino acid metabolism on early parenteral lipid and high-dose amino acid administration in {VLBW} infants – A randomized, controlled trial

Adaptive regulation of amino acid metabolism on early parenteral lipid and high-dose amino acid administration in {VLBW} infants – A randomized, controlled trial



شناسه مقاله
10.1016/j.clnu.2014.01.002
دریافت مقاله

انگلیسی

Title: Adaptive regulation of amino acid metabolism on early parenteral lipid and high-dose amino acid administration in {VLBW} infants – A randomized, controlled trial

Authors: Hester Vlaardingerbroek and Jorine A. Roelants and Denise Rook and Kristien Dorst and Henk Schierbeek and Andras Vermes and Marijn J. Vermeulen and Johannes B. van Goudoever and Chris H.P. van den Akker

Journal: Clinical Nutrition

Year: 2014

Abstract:

SummaryBackground & aims An anabolic state can be achieved upon intravenous amino acid administration during the immediate postnatal phase despite a low energy intake. The optimal dosing of amino acid and energy intake has yet to be established. The aim was to quantify the efficacy of early initiation of parenteral lipids and increased amounts of amino acids on metabolism and protein accretion in very low birth weight infants. Methods 28 very low birth weight infants were randomized to receive parenteral nutrition with glucose and either 2.4 g amino acids/(kg·d) (control group), 2.4 g amino acids/(kg·d) plus 2–۳ g lipid/(kg·d) (AA + lipid group), or 3.6 g amino acids/(kg·d) plus 2–۳ g lipid/(kg·d) (high AA + lipid group) from birth onward. On postnatal day 2, we performed a stable isotope study with [1-13C]phenylalanine, [ring-D4]tyrosine, [U-13C6,15N]leucine, and [methyl-D3]α-ketoisocaproic acid to quantify intermediate amino acid metabolism. Results The addition of lipids only had no effect on phenylalanine metabolism, whereas the addition of both lipids and additional amino acids increased the amount of phenylalanine used for protein synthesis. In addition, high amino acid intake significantly increased the rate of hydroxylation of phenylalanine to tyrosine, increasing the availability of tyrosine for protein synthesis. However, it also increased urea concentrations. Increasing energy intake from 40 to 60 kcal/(kg·d) did not increase protein efficiency as measured by phenylalanine kinetics. The leucine data were difficult to interpret due to the wide range of results and inconsistency in the data between the phenylalanine and leucine models. Conclusions High amino acid and energy intakes from birth onwards result in a more anabolic state in very low birth weight infants, but at the expense of higher urea concentrations, which reflects a higher amino acid oxidation. Long-term outcome data should reveal whether this policy deserves routine implementation. This trial was registered at www.trialregister.nl, trial number NTR1445, name Nutritional Intervention for Preterm Infants-2.

Keywords: Metabolism, Preterm infant, Parenteral nutrition, Growth, Stable isotopes

ترجمه فارسی
این متن به صورت خودکار و توسط موتور مترجم ترجمه شده است. برای سفارش ترجمه دقیق به قسمت 'سفارش ترجمه' مراجعه کنید

عنوان: مقررات تطبیقی ​​از متابولیسم اسید آمینه در چربی تزریقی اوایل و مدیریت اسید آمینه با دوز بالا در {} VLBW نوزادان – یک کارآزمایی تصادفی کنترل شده

نویسندگان: Hester Vlaardingerbroek and Jorine A. Roelants and Denise Rook and Kristien Dorst and Henk Schierbeek and Andras Vermes and Marijn J. Vermeulen and Johannes B. van Goudoever and Chris H.P. van den Akker

ژورنال: Clinical Nutrition

سال: ۲۰۱۴

چکیده:
آمار بلند مدت نتیجه باید نشان دهد که آیا این سیاست سزاوار اجرای معمول این محاکمه در wwwtrialregisternl ثبت شد، تعداد آزمایش NTR1445، نام مداخله غذایی برای نوزادان نارس-۲
کلمات کلیدی:   سوخت و ساز بدن نوزاد نارس،، تغذیه تزریقی، رشد، ایزوتوپ پایدار

سفارش ترجمه

سفارش ترجمه

توانایی ترجمه

توانایی ترجمه

  • فیلد های زیر را به عنوان نمونه کار ترجمه کنید. دقت کنید که کیفیت ترجمه در انتخاب شما به عنوان مترجم این مقاله موثر است.


دریافت مقاله